The use of __getitem()__ and __setitem() in Python allows for custom implementations in classes to enable subscripting and item assignment.
__getitem()__ can make class objects subscriptable and iterable, allowing values to be retrieved based on keys of various types.
__setitem()__ enables class objects to be assignable, setting values based on keys and values of different types.
The examples provided showcase how to implement __getitem()__ and __setitem() methods in a custom class and demonstrate their usage for retrieving and setting values in various scenarios.