<ul><li>Researchers have used artificial intelligence and evolutionary biology to develop a novel fluorescent protein, esmGFP, through their advanced AI model, ESM3.</li><li>ESM3, trained on a vast dataset of protein sequences, structures, and annotations, simulated 500 million years of molecular evolution to design esmGFP.</li><li>Despite sharing only 58% sequence similarity with its closest natural counterpart, esmGFP exhibited fluorescence in laboratory tests, showcasing the model's ability to create functional proteins not found in nature.</li><li>This breakthrough has significant implications for applications like drug discovery, environmental monitoring, and synthetic biology, offering new possibilities for developing enzymes, therapeutics, and tools for protein evolution exploration.</li></ul>

AI Simulates 500 Million Years of Evolution to Create a Novel Fluorescent Protein

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