CSS Grid layout can be frustrating due to various problems like incorrect positioning, weird gaps, alignment issues, and poor mobile responsiveness.
Common issues include elements ending up in wrong places, strange gaps between items, inconsistent alignment, and desktop designs not translating well to mobile.
Solutions involve checking container properties, using correct grid properties like gap, understanding alignment systems, and creating responsive layouts with auto-fit and media queries.
Debugging tools like Firefox's Grid Inspector, pen and paper for visualizing layouts, and explaining problems out loud can help in resolving CSS Grid issues effectively.