The sequel Deadpool & Wolverine, directed by Shawn Levy, does not require any prior knowledge of the Marvel Cinematic Universe (MCU). Levy stated that the film is designed for entertainment and does not assume viewers have done prior research.
The movie will incorporate the Time Variance Authority (TVA) introduced in the Loki series to explain Deadpool's involvement in the MCU multiverse and introduce a new version of Wolverine.
Levy aims to cater to both dedicated fans familiar with Marvel lore and casual viewers who may not have deep knowledge of the MCU.
Despite the interconnected nature of the MCU, Deadpool & Wolverine stands alone and does not rely on viewers having watched previous MCU shows or movies.