DeepMind has launched AlphaGenome, an AI model to predict how single DNA variants impact gene regulation in the human genome's non-coding regions, offering high-resolution predictions on molecular processes across 1 million DNA base pairs.
AlphaGenome outperforms existing models in sequence prediction benchmarks and variant-effect tasks, providing insights into gene function, mutation impacts, and disease mechanisms.
The architecture of AlphaGenome combines convolutional layers, transformer models, and final layers to analyze non-coding regions, improving understanding of genomic tasks.
Although AlphaGenome excels in many areas, it still faces challenges in predicting distant DNA interactions and hasn't been validated for personal genome interpretation or clinical use.