The digital therapeutics (DTx) sector for pain management and MSK disorders is gaining traction as a non-pharmacological care alternative.Digital solutions offer clinically validated interventions integrating physical rehabilitation and behavioral therapy.Over 40 DTx platforms globally evaluated for clinical rigor, innovation, and regulatory readiness.Evaluation framework based on therapeutic efficacy, technology, user experience, and commercial maturity.Top-tier companies like Kaia Health, Hinge Health, and Sword Health lead in regulatory compliance and patient outcomes.Second-tier platforms include metaMe Health, Joint Academy, and Karuna Labs with strong clinical promise and market presence.Third-tier innovators such as moveUP and EverEx show promise in early-stage and niche applications.Key trends include multimodal therapy, behavioral pain management, and maturing regulatory ecosystems.Opportunities lie in strategic growth through partnerships, regulatory clearances, and convergence of MSK and behavioral platforms.Digital therapeutics are crucial for managing chronic pain, offering effective, accessible, and personalized care solutions.