A new study reveals that linoleic acid, found in eggs and soybeans, can activate a key growth pathway in triple-negative breast cancer.
Linoleic acid, a type of fat common in Western diets, can fuel aggressive cancer growth through the mTORC1 pathway.
Omega-6 linoleic acid and omega-3 alpha-linolenic acid from food play crucial roles in cancer cell behavior.
Researchers found that linoleic acid activates the mTORC1 pathway specifically in triple-negative breast cancer cells.
The protein FABP5 acts as a fatty acid transporter in triple-negative tumors, linking linoleic acid to cancer cell growth.
High levels of linoleic acid and FABP5 were found in blood and tumor samples of triple-negative breast cancer patients.
This discovery may lead to personalized nutrition advice and potential new cancer drugs targeting the FABP5-mTORC1 pathway.
Understanding the link between dietary fats and cancer growth sheds light on the importance of tailored nutritional recommendations for cancer patients.
This research suggests that reducing linoleic acid intake could potentially slow down cancer growth in specific subtypes.
The study highlights the need for more precise cancer care by considering the impact of diet at a cellular level on cancer progression.