The average cost of a data breach stands at $4.45 million globally, doubling to $9.48 million for U.S. healthcare providers.40% of disclosed breaches involve data spread across multiple environments, expanding the attack surface.As generative AI advances, new security risks emerge, especially in healthcare, requiring proactive defense strategies.Organizations need to threat model their entire AI pipeline and implement secure architectures for deployment with large language models.Adhering to standards like NIST's AI Risk Management Framework and OWASP recommendations is crucial for risk identification and mitigation.Classical threat modeling techniques must evolve to counter complex Gen AI attacks like data poisoning and biased outputs.Continuous monitoring, AI-driven surveillance, and Explainable AI tools are essential for maintaining security throughout the AI lifecycle.Automated data discovery, smart data classification, RBAC methods, encryption, and data masking enhance control and security.Security awareness training for all users, along with a human-oriented security culture, is vital in detecting and neutralizing threats.Establishing robust security controls is crucial for the future of Agentic AI to ensure resilience against evolving security threats.