The first-ever RIBA Stirling Prize winner, the Centenary Building at the University of Salford, designed by Hodder+Partners in 1996, is at risk of demolition.
The building has stood vacant for the past eight years and could be demolished as part of a major redevelopment of the surrounding area called Adelphi Village.
The Twentieth Century Society has recently submitted a listing application to Historic England in a bid to save the building.
The Society has said demolition of the building would be 'wholly irresponsible and unnecessary'.
The building was hailed as a 'dynamic, modern and sophisticated exercise in steel, glass and concrete' by judges when it was awarded the inaugural Stirling Prize.
RIBA board chair Jack Pringle has stated that all Stirling Prize-winning buildings should be considered for listing.
While Heritage England makes its assessment, the demolition of the Centenary Building is currently being backed by a team made up of Salford City Council, the University of Salford and development company English Cities Fund.
According to the Twentieth Century Society, several other significant buildings in the UK are currently under threat.
Demolition of the building would be a test case for the heritage status of previous Stirling Prize winners as the award enters its 30th year.
The partnership claims the building is no longer fit for purpose and has 'ageing infrastructure', although the Twentieth Century Society disputes this.