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High-fat diet kills the joy of eating — and fuels obesity
- Research suggests that a high-fat diet can lead to a drop in food-related pleasure, driving obesity.
- High-fat and sugary foods activate the brain's reward system, but over time, the pleasure response can fade.
- Mice fed a high-fat diet showed less interest in calorie-dense treats, even when freely available.
- Obese individuals may take less pleasure in eating, with reduced activity in brain regions related to reward and pleasure.
- Neurotensin, a brain chemical, plays a key role in regulating dopamine and motivation in eating.
- Obese mice had lower levels of neurotensin in a brain circuit, leading to a decreased desire for high-calorie foods.
- When obese mice were put back on a normal diet, their neurotensin levels rose, and they regained interest in calorie-rich foods.
- Raising neurotensin levels in obese mice led to increased interest in food, weight loss, and improved behaviors.
- The study suggests that restoring the joy of eating could be key to controlling eating behavior in obesity.
- Research focusing on food enjoyment may lead to targeted therapies for obesity that address pleasure in eating.
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