<ul data-eligibleForWebStory="true">A significant share of major cryptocurrencies' circulating supply is currently in profit based on average on-chain purchase price.Bitcoin leads with 94.5% of holders in profit, followed by Ethereum at 88.7%.XRP, Dogecoin, Chainlink, and Cardano have lower percentages of supply in profit.Santiment warns of potential profit-taking due to high percentages of Bitcoin and Ethereum in profit.Cardano lags behind with only 46.5% of its supply in profit, potentially indicating undervaluation.Traders are navigating rising prices and potential overvaluation risks in the market.Profit-taking behavior and rotation into other altcoins may shape the next phase of the market cycle.