Developing a Next.js application with an Express server in TypeScript may lead to encountering the TS1259 error regarding default imports and the 'esModuleInterop' flag.
The TS1259 error arises due to default import issues with CommonJS modules, which can be resolved by enabling the 'esModuleInterop' flag in your tsconfig.json.
Ensure your tsconfig.json file contains 'esModuleInterop': true and validate import statements like 'import express, { Request, Response } from "express"'.
To fix the TS1259 error, restart TypeScript compiling, validate imports, compile your application, and understand the importance of 'esModuleInterop' for better module interoperability.