<ul data-eligibleForWebStory="true">Iran fired hundreds of ballistic missiles at Israel in response to an attack on its nuclear facilities, escalating tensions in the Middle East.Israel's military reported that the Islamic Republic targeted Israel with 200 missiles and about 200 drones in four waves of strikes.US forces assisted in shooting down the projectiles launched by Iran.The conflict marks a significant escalation, with Israel warning of continued airstrikes if Iran's assault persists.The fighting challenges the limits of aggression between the two nations and signals a potential prolonged conflict.Casualties were reported in Tel Aviv, with video footage showing explosions and damage in the area.Israel's air defense systems, including the Iron Dome and David’s Sling, have shown a high interception rate.The attacks have had repercussions on global markets, with the S&P 500 declining and crude oil prices surging.The conflict raises doubts about US negotiations with Iran on their nuclear program and the possibility of a diplomatic solution.Iran's Supreme Leader vowed strong action, while tensions may escalate to target US bases in the region.