Microsoft is issuing a specific error message (451 4.7.652) to indicate that the mail server has exceeded the maximum number of connections, which is related to opening too many SMTP connections.
This error message is more concrete and clear compared to generic messages, and it may become more common for bulk senders dealing with Microsoft (Hotmail/Outlook.com) domains.
The root cause of this issue could be sending too much mail too quickly, making excessive connections, not following IP warming practices, or overwhelming Microsoft's infrastructure.
To address the problem, senders are advised to slow down, reduce concurrency, follow IP warming procedures, request accommodation from Microsoft if scaling up volume, and adhere to Microsoft's sender guidelines.