Optimizing performance is a necessity for cloud-native applications built using .NET Core 8 and Azure.Poorly performing applications may lead to higher operational costs and user dissatisfaction.Best practices in .NET Core 8 and Azure can address these challenges effectively.Cloud-native applications use distributed architectures and require a multi-faceted approach to optimize performance.Efficient asynchronous programming and caching frequently accessed data can improve API performance.Using Entity Framework Core and proper query optimizations can optimize database interactions.Leveraging Azure Functions for background processing and Azure Front Door for static content delivery can boost performance.Monitoring performance with Azure Application Insights and implementing load testing and auto-scaling rules are essential strategies.Optimizing performance is an iterative process that evolves as an application scales.With .NET Core 8 and Azure, developers can build cloud-native applications that deliver exceptional performance.