Python file handling in Python allows you to work with files by opening, reading, writing, and appending data.
The 'with' statement in Python is recommended for file handling as it automatically closes files, even in case of errors.
Common file operations in Python include reading files line by line, writing data, and appending data to existing files.
Best practices for Python file handling include using the 'with' statement, handling exceptions, choosing the correct file modes, and being mindful of file paths and encodings.