Learning GUI development in Python allows applications to come to life with windows, buttons, inputs, and interactions.Tkinter is recommended for beginners in Python GUI development, and this guide focuses on using Tkinter for GUI development.Widgets are essential elements in GUI development, including buttons, labels, text inputs, checkboxes, dropdowns, and sliders.Layouts in Python GUI are managed using geometry managers like pack(), grid(), and place() for organizing widgets.The root widget in Tkinter serves as the main window for holding GUI elements and the mainloop() function keeps the app running.mainloop() is crucial for Tkinter applications' interactivity by listening for user actions and keeping the window open.Getting started with Tkinter involves creating a root window and adding widgets between the root and mainloop() for visibility.Pack layout manager in Tkinter arranges widgets relative to each other, and grid layout manager offers precise control over widget placement.PyUiBuilder simplifies the process of utilizing pack and grid layouts, making GUI development easier with drag-and-drop functionalities.Joining a Discord server for assistance in tkinter or Python GUI development is recommended for further help and guidance.