Django is a comprehensive framework that excels in security and provides authentication, database management, and scalability out-of-the-box.
Flask is a minimalistic yet powerful framework that offers flexibility and freedom to customize web applications with minimal code.
FastAPI is a modern framework known for its swift communication, automatic validation, asynchronous support, and high-speed performance.
Pyramid strikes a balance between rigidity and extreme freedom, allowing developers to choose between a micro-framework approach or a full-stack solution.