TypeScript brings static typing to JavaScript, reducing bugs and unpredictable behavior.Initially, TypeScript in Node.js required compilation to JavaScript before execution.Node.js added experimental support for TypeScript using type stripping in v22.6 release.TypeScript runners allow direct execution of TypeScript code, improving development efficiency.Node.js type stripping removes type declarations and annotations from TypeScript code.TypeScript runners handle both development steps at once and are optimized for speed.Node.js type stripping is experimental, not recommended for production yet.Using ts-node, developers can run TypeScript code directly in Node.js with type checking.tsx module is a third-party tool for executing TypeScript in Node.js with optimization.tsx uses esbuild for quick transpilation and executes TypeScript code efficiently.