The Speech Synthesis API for Text-to-Speech in JavaScript explores the historical context, web standards, and adoption in browsers.Specifications include key interfaces like speechSynthesis, SpeechSynthesisVoice, and SpeechSynthesisUtterance with methods for control.Integrating seamlessly with HTML, the API allows dynamic text-to-speech interaction on web platforms for user engagement.Code examples range from basic implementation to advanced scenarios involving voice customization and event handling.Comparisons with third-party libraries highlight cross-browser compatibility and native vs. browser implementations.Real-world applications include accessibility, educational tools, voice assistants, and dynamic content narration in marketing.Performance considerations emphasize smooth rendering, voice loading optimization, and latency reduction for speech output.Debugging techniques cover handling unsupported voices, audio output issues, and addressing user privacy concerns.The API offers a powerful tool for creating engaging web experiences, with references for further reading and best practices.