Non-consensus investments challenge popular opinion and tend to yield the highest returns in venture capital investment.The investment landscape maps consensus and conviction onto a quadrant.Consensus investments are aligned with majority opinion, while non-consensus investments may seem risky or unconventional.Non-consensus investments have radical differentiation, technological leap, and a counterintuitive approach.High-conviction, non-consensus investments can capture outsized returns if they succeed.Well-researched, high-conviction non-consensus investments provide steady returns.Deep domain expertise, rigorous due diligence and a framework for evaluating potential breakthrough technologies is required to mitigate risks.The data consistently shows that the most lucrative venture returns come from high-conviction bets that initially faced widespread skepticism.Top-quartile VC funds consistently feature a higher proportion of these contrarian bets in their portfolios.Successful non-consensus investments require patience, conviction, and a willingness to see value where others may see risk.