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The Evolution of Experimental Design

  • The field of Design of Experiments (DoE) has undergone a remarkable transformation over the past century, evolving from manually constructed designs to sophisticated computer-generated experimental plans.
  • Classical designs of this era were characterized by their elegant simplicity. Their construction relied on systematic rules: circular permutations and combinatorial principles that could be executed with just paper and pencil.
  • The 1970s marked a transformative period in experimental design, driven by the rapid growth of computing power and the emergence of algorithmic optimization methods.
  • The concept of optimality criteria became central to this revolution. Different criteria were developed to address specific experimental objectives.
  • New optimality criteria and algorithmic developments continue to expand the capabilities of computer-generated designs.
  • This convergence has created unprecedented flexibility in experimental design.
  • Modern innovations continue to emerge from both traditions. This suggests that the future of DoE will likely involve further synthesis of traditional principles with advanced computational methods.
  • Definitive Screening Designs (DSDs), Orthogonal Minimally Aliased Response Surface (OMARS) designs, and Orthogonal Main Effects Screening Designs for Mixed-Level Factors (OML designs) represent advances in classical design construction principles.
  • Current research explores the intersection of model-based and model-agnostic frameworks, promising even greater flexibility and efficiency in experimental design.
  • These developments enhance our ability to design efficient and effective experiments across diverse fields of application.

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