TypeScript's Index Signature is a helpful feature when dealing with data response whose structure is not known.Instead of using 'any' type, Index Signature allows you to define the types or interfaces of your data response dynamically.Using Index Signature, you can extend the data type as much as you like and catch other key-value pairs at once.It is recommended to define explicit response schemas if you know the structure, but Index Signature is a good alternative when unsure.