Bitcoin rose more than 8% to more than $75,000 as Donald Trump took an early lead in the US presidential election against Kamala Harris.
Bitcoin is viewed as a 'Trump trade' because Republican presidential nominee Trump embraced digital assets during his campaign.
Other tokens also rallied, with Ethereum jumping 6.5% and Dogecoin, promoted by Trump supporter Elon Musk, surging 18%.
Traders are bracing for potentially pronounced market volatility stemming from results of the election that polls show are a dead heat.
Investors in spot-Bitcoin ETFs took chips off the table a day before the election, with the 12 funds seeing a record outflow of $579.5m on 1 November, according to Bloomberg data.
Crypto-industry executives are optimistic that either of the candidates' position toward digital assets would be in sharp contrast to the crackdown on the sector under President Joe Biden.
SEC Chair Gary Gensler is a critic of the industry's alleged noncompliance, repeatedly labeling the sector as rife with fraud and misconduct.
Crypto-data platform VeloData's CEO and founder, Frederick Collins, said the rise in Bitcoin's price was tied to increases in Trump's prospects of winning.
The options market predicted moves of about 8% in either direction the day after the vote, compared with a typical 2% rise or fall on a normal day.
Funds from issuers such as BlackRock and Fidelity have attracted about $23.6bn of net inflows in 2024, according to Bloomberg data.