<ul><li>Traditionally, drug discovery focused on enzymatic reactions and receptor-based signaling in the body.</li><li>The majority of proteins without well-defined binding pockets were considered undruggable.</li><li>Protein-Protein Interaction (PPI) modulators have changed the game by stabilizing interactions between proteins.</li><li>The case of the HER2 receptor demonstrates that undruggable targets can be tackled with the right biological strategy.</li></ul>

What do we really mean by “undruggable” diseases?

Discover more