<ul data-eligibleForWebStory="true">Bitcoin and many cryptocurrencies use hash-based puzzles for proof-of-work, like tweaking transaction blocks to meet specific criteria.Litecoin and Dogecoin use the scrypt hash function, while others like Monero utilize Equihash or RandomX for proof-of-work.Hash puzzles are chosen for their difficulty to solve but ease to verify, even with quantum computing advancements.Cryptocurrencies rely on hashing functions' security for their integrity.While hash puzzles prove computational work, they do not serve any practical use beyond cryptocurrency mining.Efforts like FoldingCoin, which focus on solving useful problems like protein folding, have not gained widespread adoption.Practical work-based cryptocurrencies face challenges due to divergent incentives and potential disruptions by market participants.Hash-based problems in cryptocurrencies have adapted over time to maintain their difficulty.The use of practical problems for proof-of-work could open the door to rapid disruption if solved mathematically.Despite the potential benefits, cryptocurrencies have largely favored hash puzzles for their proof-of-work mechanisms.