<ul><li>Amino Acid Sequence Determines Structure: The sequence of amino acids in a protein (primary structure) dictates its folding pathway and final structure.</li><li>Chaperones: Specialized proteins, called molecular chaperones, assist in folding other proteins to ensure correct conformations and prevent misfolding.</li><li>Thermodynamics: Protein folding is driven by the minimization of free energy. A properly folded protein achieves its most stable, energy-efficient state.</li><li>Hydrophobic Core: Hydrophobic amino acid residues typically fold inward to avoid water, forming the core of the protein, while hydrophilic residues face outward.</li></ul>

15 points about protein folding

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