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Marcus Freeman Honored as 2024 Paul ‘Bear’ Bryant Coach of the Year

Marcus Freeman, head coach of the University of Notre Dame football team, received the College Football Coach of the Year award at the 2025 American Heart Association’s Paul “Bear” Bryant Awards.
The Fighting Irish achieved a record of 14-2 under his guidance, resulting in momentous victories against highly-ranked teams.
The award recognized Coach Freeman’s excellence in coaching and his commitment to mentoring young athletes.
The judging committee, including members from the media and previous award winners, ensures evaluation of achievements across the nation.
Other coaches were recognized for their accomplishments including Fran Brown of Syracuse University and Grant Teaff.
The awards show celebrated heart health research and education, driven by the American Heart Association’s mission to combat heart disease.
The event also embraced fan voting and community outreach, as well as Marathon Oil Corporation’s decade-long sponsorship.
Coach Freeman’s recognition signifies an accomplishment for both him and his program, emphasizing the importance of mentorship and leadership in sports and beyond.
The American Heart Association’s Paul “Bear” Bryant Awards highlights the significance of both athletic excellence and health awareness.
The collaboration between the Bryant family and the American Heart Association aims to promote cardiovascular health, fostering hope for healthier communities.

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Bioengineer

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RSClin® Tool N+ Enhances Accuracy in Recurrence Risk Estimation and Chemotherapy Benefit for Node-Positive Breast Cancer

RSClin Tool N+ is a statistical tool that is helping cancer researchers enhance the accuracy of predicting breast cancer prognosis and treatment response.
RSClin Tool N+ uses a multivariate model which amalgamates clinical variables, pathology and genetics to offer more personalized insights for tailoring chemotherapy recommendations to breast cancer patients.
This tool reinforces the progression towards integrating genomic information into routine clinical practice
RSClin Tool N+ offers a collaborative atmosphere where doctors and patients can engage deeply in treatment planning.
The model was validated against the Clalit Health Services registry, demonstrating a high degree of concordance in predictions vs. actual patient outcomes.
The integration of RSClin Tool N+ signifies a shift in the paradigm of cancer care towards personalized medicine.
The availability and accessibility of advanced cancer prognostics through platforms like Exact Sciences enhance their potential to affect patient outcomes positively.
Tools like RSClin Tool N+ are important in cancer care, as we progress towards a future where genomics and individualized therapies become the norm.
This development will advocate for further research and clinical trials aimed at refining and improving the prognostic tools that support oncologists in their effort to deliver the best care possible.
As patient insights continue to become front and center, the development of tools like RSClin Tool N+ will revolutionize how oncologists approach treatment decisions.

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Bioengineer

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Revolutionary Dual Stem Cell Therapy Introduced for Combating Brain Metastasis in Non-Small Cell Lung Cancer Patients

Scientists are exploring innovative stem cell treatment strategies for leptomeningeal brain metastasis (LBM), a manifestation of metastatic brain cancer.
Traditional therapies, like chemotherapy, have been deemed inadequate against LBM, spotlighting the need for innovative methods to combat this disease.
Researchers have developed immune-competent LBM mice models to create a reliable framework for testing new treatment protocols.
They investigated the potential of using allogeneic dual stem cells engineered to release oncolytic herpes simplex virus (oHSV) and anti-PD-1 (scFvPD-1) to augment tumor cell destruction and modulate the immunological environment surrounding tumors.
The application of dual stem cells showed notable improvements in therapeutic outcomes, primarily due to the induction of immunogenic cell death—a process crucial for stimulating the body’s immune response against tumors.
Further, the treatment activated anti-tumor T cell signaling pathways, changing the way the body fights back against the cancerous cells and made the tumors sensitive to cisplatin, a chemotherapy drug commonly used for cancers.
The findings could be transformative for LBM patients, demonstrating that localized delivery of a combination of engineered stem cells could significantly enhance treatment efficacy.
The research also showcases the importance of collaboration across various scientific fields—combining cancer biology, immunology, and innovative engineering—demonstrating how interdisciplinary approaches can advance the fight against cancer.
The role of stem cell technology in developing effective therapies for complex conditions like LBM illustrates how far treatment paradigms have evolved, moving from traditional chemotherapy to more nuanced, targeted therapies.
The promise of dual stem cell-based immunotherapy highlights a new frontier in cancer treatment, offering transformative therapies that address both the biological complexities of cancer and the therapeutic challenges posed by metastasis.

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Bioengineer

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Research Uncovers Distinct Characteristics of Early-Onset Colorectal Cancer in Racial and Ethnic Minorities

Early onset colorectal cancer is significantly increasing amongst young people and underrepresented racial and ethnic minority groups.
Researchers from Baylor College of Medicine, the University of California at Irvine, and Ben Taub Hospital examined the molecular landscape.
80% of early onset cases are sporadic, casting doubt on genetic predispositions associated with the disease.
Environmental factors, including dietary habits and the gut microbiome, may influence the development of the cancer subtype.
The researchers used whole-genome DNA methylation profiling to unveil profound alterations in epigenetic landscapes that favor tumorigenesis.
The team identified specific epigenetic alterations in metabolic genes unique to early onset colorectal cancer amongst racial and ethnic minorities.
The findings could pave the way for more tailored treatment strategies and the identification of potential biomarkers for early detection.
The research emphasizes the need for inclusivity in research studies that have disproportionately favored individuals of European descent.
The study marks a turning point in the ongoing battle against colorectal cancer, urging policymakers to take action in fostering awareness focused on this critical health issue.
The journey towards comprehensively understanding early onset colorectal cancer has only just begun, and novel findings will revolutionize cancer care.

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Bioengineer

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Could Minor Repeated Head Impacts Lead to Significant Injury?

The frequency and severity of collisions during games and practices expose athletes to significant health risks, raising essential questions about the long-term consequences of multiple, often unnoticed, head impacts.
Dr. Jeff Bazarian, a leading figure in this field at the University of Rochester, highlights the need for heightened awareness of the cumulative effects of head trauma.
The pressing question is how to effectively monitor and address the subtle yet significant neurological effects of cumulative head injuries.
As sports science continues to advance, researchers are increasingly integrating strategies from occupational medicine.
The innovative optical coherence tomography (OCT) technology holds particular promise in the realm of this research.
Furthermore, the study’s design will consider the frequency and interval between head impacts, investigating whether temporary breaks from repetitive hits could allow for recovery and avert neurological decline.
The findings from this study may ultimately guide the establishment of more robust standards for monitoring athletes’ neurological health throughout their careers.
This proactive stance on neurological wellness could mitigate the risks faced by both current and future generations of athletes.
This in-depth exploration into the impact of head injuries in sports paves the way for transformative changes in how coaches and medical staff approach training and game strategies.
The advent of this type of focused research signifies a critical evolution in sports science, shedding necessary light on an often-overlooked facet of athletic participation.

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Bioengineer

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Study Reveals Connection Between Discharge Physical Function and Hospital Readmission Rates

Deficiencies in physical function pose a significant risk of hospital readmissions among adults aged 50 and older.
17% of Medicare beneficiaries were readmitted to the hospital within 30 days of discharge between 2016 and 2020.
Identifying functional limitations before patients are discharged allows for targeted interventions aimed at improving those abilities.
The study highlights the need for healthcare institutions to develop strategies that prioritize functional health assessments as part of routine care.
Enhancing patients’ functional abilities before they leave the hospital may help prevent future hospitalizations due to reduced function or complications arising from such impairments.
Strong associations between functional impairments and the incidence of hospital readmissions are seen across various health conditions.
The study also underscores the necessity of collaborative care models for better communication and information sharing among healthcare teams.
Physical function is a crucial indicator of underlying health, and accurate assessments of patients preparing for discharge are complex yet vital.
Prioritizing functional assessments for all clinicians and making this information widely available to the treatment team at the receiving end of care transitions is essential.
The findings from this study present a compelling case for enhancing the assessment of physical function within hospital settings for older patients.

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Bioengineer

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Empowering Resistance: The Role of Soybeans in Battling Nematode Invaders Unveiled

The study published in the journal Molecular Plant-Microbe Interactions reveals the genetic responses of soybean varieties when faced with soybean cyst nematodes.
Researchers led by Mst Shamira Sultana at the Hewezi Lab of the University of Tennessee used RNA sequencing to discover gene expression patterns within soybean roots.
The findings from the study highlight the critical importance of genetic factors in determining a plant’s ability to withstand nematode attacks.
Those soybean varieties that upregulate genes linked to immune responses are able to mount a robust defense against nematode intrusion.
The research also discovered that specific genes are regulated differently depending on the resistance status of the soybean variety.
The study’s findings suggest opportunities for targeted breeding approaches, as agronomists could develop soybean strains that naturally resist nematode infections.
This could reduce farmers' reliance on chemical treatments, paving the way for more sustainable agricultural practices.
Creating soybean cultivars that resist nematodes not only aids farmers, but it also contributes to global food security efforts.
This research also opens doors to interdisciplinary collaborations within the scientific community, including fields such as molecular genetics, genomics, and ecology.
Understanding how plants interact with pests at a genetic level can inform ecological management strategies that promote healthy ecosystems and enhance biodiversity.

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Bioengineer

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INTROPY: Innovative Cancer Treatment by Targeting Mechanotransduction

Pere Roca-Cusachs Soulere, Professor at the Faculty of Medicine and Head of the Cellular and Molecular Mechanobiology group at Institute for Bioengineering of Catalonia (IBEC), has been awarded an ERC Proof of Concept Grant.
The grant is designed to help researchers explore the commercial and societal impacts of scientific projects previously funded by the ERC.
Roca-Cusachs is embarking on an innovative project (INTROPY) to investigate the inhibition of mechanotransduction as a novel therapeutic avenue for cancer treatment.
Mechanotransduction refers to the conversion of mechanical stimuli into biochemical signals, influencing biological processes like tumor progression and wound healing.
Changes prompted by tumor activity is the stiffening of surrounding tissues, which is common in cancers that accelerates tumor growth.
Roca-Cusachs and his team have identified a protein interaction involved in mechanotransduction and are proposing a therapeutic strategy aimed at inhibiting these specific proteins, thereby disrupting the mechanotransduction pathways that contribute to cancer progression.
They have identified six small molecules that demonstrate considerable potential in targeting these proteins.
The team's research may lead to the introduction of the first mechanoinhibitor drug, which would represent a pioneering advancement in the treatment of cancers characterized by mechanical stress responses, focusing on breast and pancreatic cancer alongside fibrosis.
The research could resonate well beyond oncology as the mechanisms underlying mechanotransduction are relevant to various other medical conditions.
The insights gained from the INTROPY project could influence therapeutic approaches across a spectrum of diseases characterized by dysfunctional mechanotransduction.

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Bioengineer

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Terahertz Pulses Create Chirality in Non-Chiral Crystals: A Breakthrough Discovery

Researchers from the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) have developed a novel method for inducing chirality in non-chiral materials using terahertz light.
The ability to manipulate chirality dynamically in a controlled environment could have a transformative impact on material science and technological advancements.
Chirality plays a significant role in determining the physical properties of materials and is particularly crucial in emergent technologies such as optoelectronics and quantum computing.
The researchers utilized high-intensity terahertz light to disturb the delicate balance within boron phosphate (BPO4), a non-chiral material, thereby inducing chirality.
This work opens new avenues in the design of materials with tailored optical responses, which could prove to be revolutionary for devices relying on chirality, such as organic light-emitting diodes (OLEDs).
Control over chirality direction could lead to leaps in device performance and impact several sectors, including telecommunications, computing, and renewable energy.
Furthermore, this capability could transform optoelectronic platforms by enabling better interaction between light and matter and paving the way for advances in imaging technologies and sensors.
The interplay of chiral structures in biological systems suggests that this research could also inform the development of new drugs or treatments.
As we continue to push the boundaries of material science, dynamic control over chirality may become a crucial tool in the arsenal of future innovations.
This pioneering research has opened extraordinary avenues in controlling chirality within non-chiral materials through the inventive use of terahertz light.

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Bioengineer

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Researchers Unveil Innovative AI Technique for Predicting Cyclone Rapid Intensification

Researchers at the Institute of Oceanology of the Chinese Academy of Sciences have used machine learning to create a new forecasting model aimed at improving prediction for tropical cyclone rapid intensification.
The dual-input system employs a method called contrastive learning, which enables the model to compare a new and unknown sample with a bank of 10 known rapid intensification cases to identify key similarities and differences.
The new system, which uses satellite imagery with atmospheric and oceanic data to level out an analytical dataset, achieved an accuracy rate of 92.3% when applied to data from the Northwest Pacific region between 2020 and 2021.
Notably, the new technology reduced the false alarm rate to only 8.9%, outperforming current forecasting methods and potentially bolstering global disaster preparedness plans.
Prof. LI Xiaofeng, the corresponding author of the study, emphasised that 'This study addresses the challenges of low accuracy and high false alarm rates in RI TC forecasting. Our method enhances understanding of these extreme events and supports better defenses against their devastating impacts.'
The implications of this advanced forecasting model are profound, particularly in terms of enhancing early warning systems, which can empower communities to make informed decisions and ultimately save lives and minimize property damage during intense weather events.
As of yet predominantly being applied in reanalysis data sets rather than live analysis, the validation of the model’s performance within operational scenarios signifies an important development, paving the way for more reliable real-time meteorological prediction.
Advancements such as these demonstrate the need for innovation in weather forecasting, and have the potential to significantly enhance global resilience against extreme weather phenomena in an era of changing climate.
As on-going research continues to explore the depths of machine learning applications within meteorological sciences, the findings from this study serve as an inspiring benchmark, moving us closer to a future where accurate forecasting of tropical cyclone behavior is not only a formidable scientific challenge but a consummate reality through the integration of cutting-edge technology.

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Bioengineer

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University of Oklahoma Secures Federal Funding to Enhance Health Care Access Throughout the State

The University of Oklahoma received $1.2 million in federal funding to integrate NIH-funded clinical trials in primary care settings in underserved areas including rural regions of Oklahoma and Tribal nations.
The CARE for Health™ initiative aims to ensure that all patients receive standard treatments and also benefit from latest medical research.
The University of Oklahoma brings decades of experience in primary care research to the initiative through Zsolt Nagykaldi, who brings his expertise as a professor and director of research at the Department of Family and Preventive Medicine.
The initiative builds on a pilot program launched by the NIH last year and is aimed at creating a lasting infrastructure for clinical research that prioritizes health equity and accessibility.
Research team aims to create solutions that facilitate greater participation and more accurate data collection by addressing specific challenges faced by rural patients.
The university has pledged to assist primary care practices in efficiently gathering data from electronic health records (EHR) to ensure that it takes far less than the average of 17 years for medical research findings to be utilized in everyday clinical practice.
The CARE for Health™ initiative represents a holistic approach to health equity, and the University of Oklahoma's contributions help to advance health outcomes.
The challenge remains to ensure that underrepresented populations benefit from these innovative healthcare strategies.
The CARE for Health™ initiative sets a precedent for future research models across the nation, prioritizing participant accessibility and addressing the specific needs of rural populations.
The University of Oklahoma mission is to enhance health equity across the state of Oklahoma and beyond through its involvement in the CARE for Health™ initiative.

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Medium

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I think the beginning is the best place to start a story, don’t you?

The author began writing in a diary, expressing their thoughts, emotions, and stories.
The author's mother supported their writing and bought them more diaries and journals.
The author dedicates their stories to their mother and late partner.
The author expresses their writing voice and invites readers to join their imaginative world.

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Bioengineer

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U of M Medical School Study Reveals Financial Strain of Medical Equipment on Cancer Survivors

A recent study conducted by the University of Minnesota Medical School on the costs associated with medical equipment used by cancer survivors, sheds light on the economic burdens faced by cancer survivors in the United States.
The study reveals an alarming trend regarding the financial responsibilities associated with medical equipment, and underscores its significance as a significant component of out-of-pocket healthcare costs.
The prevalence of cancer survivors relying on medical equipment nearly doubled from 1999 to 2018, increasing from 6.6% to 8.6%.
The research reveals that cancer survivors must bear an average of 39% of the cost-sharing responsibilities for medical equipment, while sharing costs with prescription drugs (9%), outpatient care (4%), and hospitalizations (1%).
Insurance plans provide insufficient coverage when it comes to medical equipment, and patients often encounter labyrinthine bureaucracies and daunting administrative tasks while trying to secure coverage for much-needed devices.
As the survivor community grows in numbers, the financial disparities in accessing medical equipment should be a top priority for healthcare systems, policymakers, and healthcare providers.
Reducing the financial responsibility of cancer survivors in acquiring essential equipment is paramount in promoting health equity among affected populations.
The commitment to addressing this financial burden emerges as a vital aspect of promoting optimal cancer survivorship, and initiatives designed to streamline the procurement of medical equipment and reduce out-of-pocket costs are critical components of a comprehensive approach to enhancing the quality of life for cancer survivors.
Only through dedicated efforts to improve access to affordable medical equipment can we truly honor the journey of cancer survivors and provide them with the support they need to thrive.
This research opens a crucial dialogue about the imperatives of equitable healthcare and the role of policy in shaping the landscape of survivorship.

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Bioengineer

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Enhancing This Molecule May Aid Muscle Preservation During Fat Loss

Researchers from the Salk Institute recently announced a breakthrough discovery: BCL6 levels play a key role in muscle maintenance. The researchers found strong evidence that suggests enhancing the levels of BCL6 can help preserve muscle mass while shedding unwanted fat. The protein helps regulate IGF1 production, which is crucial in stimulating muscle growth and repair.
The study also revealed that in mice lacking BCL6 the muscle mass was reduced by 40%. This is an important finding for millions of adults in the United States who have a concern about losing muscle mass along with fat. Particularly for the one in eight adults in the US who are utilizing GLP-1 medication which poses risks of unwanted muscle loss during weight reduction.
The research also suggests potential for pairing GLP-1 medications with a BCL6 boosting drug that could revolutionize patient care, offering a therapeutic route that mitigates the risks associated with rapid weight loss.
This study speaks of a new era of treatment involving BCL6 augmentation. Patients aiming to lose weight without sacrificing their muscle mass may potentially benefit from this groundbreaking research.
Expanding the research to include longer periods of fasting and its effects on BCL6 could yield significant insights into how dietary habits influence muscle mass over time. These findings could have broader implications for nutritional strategies aimed at promoting health in aging populations facing dual challenges of weight management and muscle maintenance.
Intricate biochemical mechanisms are at play when the body experiences fasting. Fasting triggers the stomach to release ghrelin, a hormone that signals hunger to the brain and initiates a cascade of biochemical responses. Growth hormone is then released, which plays a pivotal role in regulating metabolism and the growth of tissues, including muscles.
Understanding when and how BCL6 levels fluctuate can inform future treatments not only for those on weight loss medications but also for older adults and individuals with conditions like cancer or sepsis, who are particularly susceptible to muscle wasting.
The study serves as a clarion call for ongoing research in this field. With significant clinical implications, this work could mark a turning point in our understanding of muscle biology and open new avenues for treating complications associated with muscle loss.
BCL6-based nutritional strategies aimed at promoting muscle maintenance, particularly in aging populations, may well become a mainstay of health optimization, with the potential to revolutionize the way we approach this critical component of vitality and overall wellbeing.
Overall, the innovative methods employed in this study highlight the power of using advanced technologies and databases to uncover molecular interactions that govern our biological processes. The study maintains a broad scope of understanding among researchers from various institutions collaborating on this significant research.

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Bioengineer

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NJIT Physicist Dale Gary Honored as Fellow of the American Astronomical Society

Dale Gary, a distinguished professor from New Jersey Institute of Technology has been named as one of the recipients of American Astronomical Society's (AAS) 2025 Fellows for his contributions to solar research and radio astronomy.
He has been recognized for his outstanding contributions to solar physics and radio astronomy, specifically for his innovative work that has led to new insights into solar energetic processes.
Gary has been praised for his “outstanding national and international leadership” within solar radio engineering and solar physics.
He has been a continuous member of AAS, and his active engagement in this society has taken shape through various elected roles.
Gary’s nearly 40-year career has been primarily focused on utilizing radio observations to explore the explosive energy releases originating from the Sun. His body of work has significantly advanced the field of solar physics.
Central to Gary’s research activities is the Owens Valley Solar Array, an NSF-supported solar radio telescope located in California.
Notably, his pioneering studies have discovered critical linkages between solar radio bursts and their effects on Earth’s technology, particularly GPS systems.
The scientific community has acknowledged Gary’s advancements in solar radio instrumentation, culminating in the recent elevation of the Frequency Agile Solar Radiotelescope (FASR) as the number one midscale project priority.
The 2025 class of Fellows will be honored in a ceremony that celebrates their groundbreaking work and contributions to astronomy.
Gary’s recognition comes on the heels of fellow NJIT-CSTR professor Philip R. Goode, who was named an AAS Fellow in 2021.

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