<ul><li>Researchers have discovered a mechanism of centromere inactivation in human cells that occurs during the aging process.</li><li>The decline in the levels of the histone H3 variant CENP-A and centromeric proteins CENP-C in aging cells is attributed to p53 activation, leading to the inactivation of centromeres.</li><li>The recruitment of lysine-specific demethylase 1 (LSD1) to centromeres in aged cells plays a role in transcriptional repression, and inhibiting LSD1 restores centromeric function.</li><li>Dual inhibition of p53 and LSD1 not only restores centromeric function but also improves the cell cycle potential and genome stability in aging cells.</li></ul>

A Youth Injection for Aging Cells

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