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ACS Annual Report: Cancer Mortality Declines Even as Incidence Rates Climb for Women; New Diagnoses in Women Under 65 Surpass Those in Men

  • The American Cancer Society’s annual report, Cancer Statistics 2025, reveals a complex picture of cancer in the U.S.
  • While progress is evident in declining mortality rates, troubling trends are emerging regarding cancer incidence, especially among younger demographics and women.
  • The cancer mortality rate has plummeted by 34% from 1991 to 2022, translating to an estimated 4.5 million lives saved.
  • However, cancer incidence rates are climbing for numerous types of cancer, particularly in women and among younger adults, thus challenging clinical and public health strategies.
  • Incidence rates among women aged 50 to 64 exceed those of their male counterparts for some cancers.
  • Lung cancer rates in individuals below the age of 65 have surpassed those in men, underscoring the need for tailored cancer prevention and treatment programs targeting women.
  • 2025 will witness approximately 2,041,910 new cancer diagnoses in the United States, breaking down to approximately 5,600 cases diagnosed each day.
  • Pancreatic cancer is now identified as the third leading cause of cancer mortality in the U.S., with an alarmingly low five-year survival rate of merely 8% for pancreatic exocrine tumors.
  • The report underscores the existence of stark inequalities in cancer mortality rates, posing challenges for health equity across racial and ethnic demographics.
  • Children and adolescents are experiencing shifts in cancer growth, with the mortality rates plummeting due to improved leukemia treatment.

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