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An Alternative to the Linear-Quadratic Model

  • The linear-quadratic model and the multi-target single-hit (MTSH) model are discussed as alternatives to describe cell survival curves following exposure to ionizing radiation.
  • Both models have parameters that affect cell survival probability, with differences in behavior at small and large radiation doses.
  • The MTSH model falls off exponentially at large doses, while the linear-quadratic model falls off quadratically. Each model provides insights into cell survival under radiation.
  • The choice between these models depends on experimental data and assumptions, with considerations for extrapolating behavior from large dose measurements to determine appropriate model parameters.

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