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Association for Molecular Pathology Releases Best Practice Guidelines for Clinical HRD Testing
- The Association for Molecular Pathology (AMP) has released best practice guidelines for HRD testing in clinical cancer laboratories to standardize detection.
- HRD is a genomic instability trait found in various cancers, affecting DNA repair and sensitivity to PARP inhibitors.
- Current HRD testing methods lack consistency, prompting AMP to establish unified recommendations with leading professional bodies.
- The guidelines focus on assay development, validation, interpretation, and detection of genomic scars using NGS platforms.
- The recommendations aim to enhance the reliability and clinical relevance of HRD testing to guide precision oncology.
- AMP's guidelines address technical challenges, tumor heterogeneity, and evolving scientific knowledge in HRD testing.
- Standardized HRD testing holds promise for expanding precision oncology beyond BRCA mutations to benefit a broader patient population.
- The guidelines emphasize multidisciplinary collaboration for optimal sample handling, data interpretation, and clinical integration.
- AMP's HRD testing guidelines aim to improve assay reliability, patient outcomes, and facilitate regulatory approvals.
- The recommendations signify a significant advancement in molecular diagnostics for cancer, promoting transparency and standardization.
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