Researchers have identified specific molecular signatures in blood and urine that correlate strongly with the consumption of ultra-processed foods (UPFs), offering a new way to objectively measure UPF intake.
Traditional dietary recall tools' limitations in assessing UPF consumption have been overcome by the discovery of biomarkers that provide a more accurate assessment of dietary intake.
A study using metabolomic profiling techniques identified metabolites associated with the proportion of dietary energy from UPFs, leading to the creation of poly-metabolite scores for objective dietary assessment.
Poly-metabolite scores were found to be statistically predictive of self-reported UPF intake and could serve as effective proxies for dietary assessment in large epidemiological studies.
A controlled feeding trial confirmed the validity of poly-metabolite scores in discriminating between diets high in UPFs and those without, highlighting their potential for clinical and population research.
The biomarkers offer an opportunity for personalized nutrition, refined across diverse populations to enhance their utility in global nutritional surveillance and public health efforts.
The study's design combining metabolomics with a controlled feeding trial enhances confidence in the biomarkers, allowing for a comprehensive assessment of dietary exposures and metabolic responses.
The biomarkers could revolutionize dietary assessment, providing insights into the complex relationship between UPFs and chronic diseases, thereby informing targeted dietary guidelines and public health strategies.
Objective biomarker data from the study have implications for regulatory policies, monitoring dietary shifts, and fostering accountability among food producers to address health challenges related to ultra-processed foods.
The research received support from the NIH and Brazil's research foundation, reflecting an international effort to tackle public health issues associated with ultra-processed foods.
The identification and validation of poly-metabolite scores offer a significant advancement in understanding UPF consumption and its health impacts, aiding in the development of population-wide strategies against diet-related diseases.