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Breakthrough Lipid Nanoparticle Therapy Shows Promise in Halting Tumor Growth and Reinstituting Tumor Suppression
- Scientists at Brigham and Women's Hospital in Boston have developed a powerful new therapeutic approach against prostate cancer.
- Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) often loses efficacy in prostate cancer, while the androgen receptor (AR) transcription factor becomes overactive.
- Existing treatment modalities have not yet successfully targeted both factors simultaneously in advanced prostate cancer.
- The novel approach, which delivers messenger RNA and small interfering RNA via lipid nanoparticles, attempts to resolve the imbalances of cellular growth and inhibition by restoring essential tumor suppressors and inhibiting tumor promoting factors.
- The researchers designed the lipid nanoparticles to carry the therapeutic mRNA and siRNA strands, ensuring their stability and effectiveness within a tumor's hostile microenvironment.
- Using preclinical models, the team found that when mRNA encoding for PTEN and siRNA targeting AR were administered together, the approach had a synergistic anti-tumor effect.
- The research could be transformative in terms of treating advanced prostate cancer by paving the way for multi-factorial therapy options.
- The approach shows promise for other cancers as well, giving the hope of more effective treatment opportunities.
- The research highlights the importance of interdisciplinary collaboration in tackling medical challenges like cancer.
- Funding for the research was provided by the National Institutes of Health.
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