A groundbreaking study reveals a non-invasive technique to enhance brain waste clearance through mechanical stimulation.The research identifies lymphatic vessels under facial skin aiding in cerebrospinal fluid drainage, crucial for brain health.Cerebrospinal fluid transports waste like amyloid-β and tau proteins, linked to Alzheimer's and neurodegeneration.Aged animal models show that superficial lymphatics maintain drainage efficiency despite aging.A handheld mechanical stimulator reinstated CSF drainage in aged mice, highlighting its efficacy.The newly discovered lymphatic network offers a feasible target for age-related neurodegenerative disorders.This approach could revolutionize neurological disorder treatments through non-invasive interventions.Stimulating CSF outflow via cervical lymphatics may impact neuroimmune interactions, aiding in various neurological conditions.The study emphasizes the importance of lymphatic vessels in brain waste disposal and potential therapeutic applications.The research signifies a significant advancement in neurovascular biology and potential therapeutic innovation.