A naukri.com initiative
Bioengineer
1w
164
Image Credit: Bioengineer
Convergence of Mutations Fuels Autoimmune Disease Linked to Infections
- Researchers at the Garvan Institute of Medical Research in Sydney, Australia, have identified a novel mechanism that calls into question the traditional “molecular mimicry” theory behind autoimmune responses.
- Their research highlights the role of hepatitis C virus (HCV) in inducing autoimmune reactions, specifically cryoglobulinemic vasculitis, instead of the traditional hypothesis of viral proteins mimicking host proteins.
- Advanced single-cell analysis and whole-genome sequencing revealed the presence of rogue clones of B cells, leading to the development of cryoglobulinemic vasculitis.
- Rather than an immune system confused by viral mimicry, it appears that the viral context establishes an environment conducive to aberrant B cell mutation and proliferation.
- This discovery, which has larger implications for autoimmune disease treatment and prediction, could lead to targeted therapies aimed at addressing the root cause of these diseases.
- Moreover, the research captures how a “perfect storm” of genetic mutations occurs in the presence of chronic viral infections.
- These findings could lead to innovative approaches to autoimmune disease treatment, shifting from symptomatic management towards understanding and intervening at the genetic level.
- Ultimately, this new understanding could enable healthcare professionals to refine treatment approaches for those at risk of developing autoimmune complications following viral infections.
- The Garvan Institute researchers are dedicated to investigating the complex interactions between pathogens and the immune system to pave the way for innovative therapies for patients suffering from autoimmune diseases that arise due to chronic infections.
- Overall, this discovery offers an exciting avenue for future research and therapeutic development, targeting the causative processes that underpin autoimmune disease development stemming from viral infections.
Read Full Article
9 Likes
For uninterrupted reading, download the app