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Cortical Microstructure Abnormalities Link Lewy Bodies, Alzheimer’s
- A study published in 2025 shed light on cortical microstructural abnormalities in dementia with Lewy bodies (DLB) and their links to Alzheimer’s disease (AD) copathologies.
- DLB, characterized by alpha-synuclein aggregation, often coexists with AD pathologies like beta-amyloid plaques and tau tangles, complicating diagnosis and understanding.
- Advanced neuroimaging techniques revealed cortical microstructural abnormalities in DLB patients, impacting cognition and sensorimotor integration.
- The study showed that greater AD-related copathology burden exacerbates cortical microstructural disruptions in DLB individuals.
- The interplay between alpha-synuclein and AD pathologies may severely impair neuronal functions and disrupt cortical microcircuits in DLB.
- Microstructural MRI abnormalities could provide early biomarkers, aiding in early diagnosis and monitoring disease progression in DLB and AD.
- Distinct neuritic alterations in DLB patients could enhance differential diagnosis from AD, guiding tailored management strategies more accurately.
- The multidisciplinary approach and large cohort in the study strengthen the causal inferences and set a new standard for investigating neurodegenerative diseases.
- Longitudinal studies are recommended to track cortical microstructural changes over time and explore biomarkers predictive of disease progression for improved prevention strategies.
- The integration of neuroimaging biomarkers with molecular data signifies a shift towards precision neurology, offering insights into dementia heterogeneity and personalized treatment approaches.
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