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Decoding Cancer’s Secret Language: The SOLFEGE Project Unveils Cell Communication Mysteries
- The SOLFEGE project, led by the Institute for Bioengineering of Catalonia (IBEC), aims to unravel the intricate cellular communication networks within the tumor microenvironment.
- Funded by the Human Frontier Science Program, SOLFEGE focuses on how various cell types coordinate behaviors through soluble factors in tissues.
- The project integrates experimental methods like cellular barcodes and controlled release of soluble factors to understand immune responses in tumor models.
- IBEC's role includes advanced imaging and spatial biotechnology to visualize cell and signaling molecule distribution in tissue architectures.
- SOLFEGE's goal is to decode how diverse cells communicate via diffusible signals and how these interactions influence cancer progression.
- By simulating the tumor microenvironment in organoid cultures, researchers can study the effects of individual and combined soluble factors.
- The project aims to identify new targets for immunotherapy by understanding the context-dependent nature of signaling pathways.
- Deciphering the molecular language of cells in tumors may lead to disrupting immune suppression and metastasis, benefiting cancer therapy.
- SOLFEGE exemplifies interdisciplinary research's transformative power in unveiling the complexities of the tumor microenvironment.
- By advancing knowledge on cellular coordination via soluble factors, SOLFEGE sets new standards for investigating cancer biology and therapy development.
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