<ul data-eligibleForWebStory="true">Researchers demonstrate that incorporating knee alignment information enhances deep-learning models predicting ground reaction forces during walking.The study compared various deep-learning architectures and found personalized biomechanical data improved accuracy.A 2D-CNN-LSTM hybrid model outperformed complex models like ResNet50 and Inception in GRF prediction.Tailored model design with knee alignment data provided superior accuracy with reduced computational demand.Accurate GRF prediction aids in diagnosing gait issues, customizing interventions, and improving rehabilitation outcomes.Integrating knee alignment in wearable systems could revolutionize biomechanical health monitoring.The study highlights the significance of subject-specific data in enhancing model sensitivity to individual biomechanics.Pretrained models like ResNet50 struggled in time-series GRF prediction, emphasizing the need for specialized architectures.Further exploration is required to optimize the integration of static biomechanical parameters with temporal sequence models.The research advocates for personalized machine learning frameworks in biomechanics for more accurate predictions.