Researchers propose DeepOFormer, a deep operator learning framework for fatigue life prediction.It addresses the challenge of overfitting using a transformer-based encoder and a mean L2 relative error loss function.Domain-informed features, such as Stussi, Weibull, and Pascual and Meeker (PM), are considered to improve prediction accuracy.DeepOFormer achieves superior performance compared to state-of-the-art deep/machine learning methods in predicting fatigue life in aluminum alloys.