Decision-Focused Fine-tuning (DFF) is a novel framework that combines decision-focused learning (DFL) with the predict-then-optimize (PO) approach.DFF addresses challenges such as deviation from physical significance and non-differentiable or black-box models.It maintains the proximity of the DL-enhanced model to the original predictive model within a defined trust region.DFF demonstrates improved decision performance and adaptability to a broad range of PO tasks in diverse scenarios.