A naukri.com initiative
Bioengineer
2w
324
Image Credit: Bioengineer
Discovery of Novel Gene Essential for DNA Repair Unveiled by Researchers
- Cells face threats from DNA damage, with up to 100,000 lesions daily, including severe DNA double-strand breaks.
- DNA damage response (DDR) involves recognition, cell cycle arrest, and signaling for repair mechanisms.
- Research reveals the significance of ZNF280A gene in DNA repair processes.
- ZNF280A gene on chromosome 22 is linked to 22q11.2 distal deletion syndrome and severe clinical symptoms.
- Loss of ZNF280A correlates with microcephaly, cognitive impairment, and growth defects in patients.
- Study investigates ZNF280A's role in genomic stability and potential DNA repair deficiencies.
- Novel screening method identifies ZNF280A's importance in repairing DNA double-strand breaks.
- Researchers establish a connection between ZNF280A expression levels, genomic stability, and clinical symptoms.
- Introduction of ZNF280A gene into patient-derived cells partially restores DNA repair mechanisms.
- Study sheds light on DNA repair mechanisms, genetic disorders, and potential therapeutic strategies.
- Research published in Nature Cell Biology highlights the significant role of ZNF280A in DNA repair and genetic disorders.
Read Full Article
19 Likes
For uninterrupted reading, download the app