Efficient Fine-Tuning of Single-Cell Foundation Models Enables Zero-Shot Molecular Perturbation Prediction
Researchers present a study on predicting transcriptional responses to novel drugs for biomedical research and drug discovery.
They leverage single-cell foundation models pre-trained on a wide range of single cells, allowing molecular conditioning while preserving biological representation.
The approach enables efficient fine-tuning and zero-shot generalization to unseen cell lines, demonstrating state-of-the-art results in model performance.