The 'Cannot Load Driver Class: com.mysql.jdbc.driver' issue in Spring Boot arises when the application can't load the old MySQL driver class due to a mismatch in driver configuration.
In older Spring Boot 1.x versions, the driver class name is explicitly set in the configuration, while in Spring Boot 2+, it can be auto-detected based on the JDBC URL.
If the Spring Boot application is upgraded to a higher version with a mismatched driver class configuration, it can lead to the 'Cannot Load Driver Class' exception.
To resolve this, ensure compatibility between MySQL Connector/J version and the driver class configuration in Spring Boot application properties.