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Forebrain Progenitors Restore Brain Function Post-Stroke
- A team led by He, X., Chen, J., and Zhong, Y. demonstrated the ability of forebrain neural progenitors to restore lost neural functions post-stroke.
- Published in Nature Communications, the study unveils insights into cellular and molecular mechanisms behind brain repair.
- Current stroke interventions focus on immediate damage mitigation, prompting exploration of stem cell-based treatments like neural progenitors.
- Forebrain neural progenitors integrated into damaged brain circuits, exhibiting synaptic connectivity and functional participation.
- Researchers traced grafted progenitors' fate using advanced imaging techniques and identified region-specific gene expression guiding circuit formation.
- Transplanted progenitors in rodent stroke models proliferated, formed synaptic contacts, and functioned similarly to endogenous neurons.
- Behavioural assessments showed significant improvements in motor coordination and cognitive function in animals receiving progenitor transplants.
- Molecular analyses revealed upregulated pathways aiding in neural repair within the grafted cells.
- Safety assessments indicated no tumorigenicity or immune rejection issues with the therapy, enhancing its translational potential.
- The study highlights the temporal dynamics of progenitor transplantation efficacy, offering a promising therapeutic window post-stroke.
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