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From Brownian Motion to Virtual Biopsy: A Historical Perspective from 40 years of Diffusion MRI

  • Denis Le Bihan recently published an open access review article in the Japanese Journal of Radiology titled “From Brownian Motion to Virtual Biopsy: A Historical Perspective from 40 years of Diffusion MRI”
  • The article explores in depth several of the concepts that Russ Hobbie and I describe in Section 18.13 (Diffusion and Diffusion Tensor MRI) of Intermediate Physics for Medicine and Biology.
  • Diffusion MRI was born in the mid-1980s, and since then, it has enjoyed incredible success over the past 40 years, both for research and in the clinical field.
  • Clinical applications began in the brain, notably in the management of acute stroke patients. Diffusion MRI then became the standard for the study of cerebral white-matter diseases, through the diffusion tensor imaging (DTI) framework.
  • Over time, clinical applications of diffusion MRI have been extended, notably in oncology, to diagnose and monitor cancerous lesions in almost all organs of the body.
  • Diffusion MRI works because spins that are excited by a radiofrequency pulse will then diffuse away from the tissue voxel being imaged, degrading the signal.
  • Le Bihan claims that the other big advances in MRI of that era—the development of functional MRI based on the blood oxygenation level dependent (BOLD) imaging—has not yet led to any clinical applications, while diffusion imaging has several.
  • Diffusion MRI has become a pillar of modern medical imaging with broad applications in both clinical and research settings, providing insights into tissue integrity and structural abnormalities.
  • It allows to detect early changes in tissues that may not be visible with other imaging modalities.
  • If you want to learn more about diffusion MRI, I recommend Le Bihan’s article. It provides an excellent introduction to the subject, with a fascinating historical perspective.

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