<ul><li>Proteins are crucial in biological systems and understanding their functions is essential.</li><li>GLProtein is a novel framework for protein pre-training that integrates global structural similarity and local amino acid details for improved prediction accuracy and functional insights.</li><li>GLProtein combines protein-masked modeling, triplet structure similarity scoring, protein 3D distance encoding, and substructure-based amino acid molecule encoding.</li><li>Experimental results show that GLProtein surpasses previous methods in various bioinformatics tasks like predicting protein-protein interaction and contact prediction.</li></ul>

GLProtein: Global-and-Local Structure Aware Protein Representation Learning

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