Advances in digital pathology and deep learning enable the integration of pathology slides and medical records for more accurate CRC risk prediction.
A transformer-based model for histopathology image analysis was adapted to predict 5-year CRC risk using data from the New Hampshire Colonoscopy Registry.
Training the model to predict intermediate clinical variables improved 5-year CRC risk prediction compared to direct prediction.
Incorporating both imaging and non-imaging data further improved performance compared to traditional features from colonoscopy and microscopy reports.