A study from the University of Pittsburgh School of Medicine reveals early neural predictors of infant emotional development.White matter microstructural patterns at 3 months forecast emotional reactivity changes by 9 months.Using NODDI imaging, researchers linked white matter characteristics to emotional trajectories.Increased neurite orientation dispersion in the forceps minor correlates with heightened negative emotionality.Complexity in the left cingulum bundle is associated with enhanced positive emotional development.The research's longitudinal design and replication validate the observed brain-behavior relationships.Identifying infants at risk for emotional dysregulation early could transform pediatric mental health interventions.NODDI's capability in mapping infant white matter development surpasses traditional imaging methods.Understanding specific white matter tracts aids in deciphering early emotional processing and regulation.The study raises questions on the stability of microstructural markers and the influence of interventions on white matter development.