Stress is a significant factor impacting health, with chronic stress linked to various medical conditions.Measuring stress levels accurately in real-time has been challenging due to imprecise tools.Engineers at Tufts University have developed innovative dental floss that monitors cortisol levels in saliva.The dental floss merges microfluidics and molecular imprinting technology for on-demand cortisol detection.The device resembles an ordinary floss pick but contains electrodes designed to recognize cortisol molecules.The use of electropolymerized molecularly imprinted polymers allows for selective cortisol detection.This technology can be adapted to monitor other biomarkers like estrogen, glucose, and cancer markers.The accuracy of the dental floss cortisol sensors matches the best commercial devices available.Potential applications include monitoring other health markers and developing multiplexed sensors for comprehensive health profiling.A startup is being developed to bring this dental floss sensor to the consumer market for routine stress monitoring.